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> Rönnblom Lars
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Potential associati...
Potential association of muscarinic receptor 3 gene variants with primary Sjogren's syndrome
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- Appel, Silke (author)
- Broegelmann Research Laboratory, The Gade Institute, University of Bergen, Bergen, Norway
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- Le Hellard, Stephanie (author)
- Department of Clinical Medicine, University of Bergen, Bergen, Norway
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- Bruland, Ove (author)
- Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway
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- Brun, Johan G. (author)
- Department of Rheumatology, Haukeland University Hospital, Bergen, Norway
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- Omdal, Roald (author)
- Clinical Immunology Unit, Department of Internal Medicine, Stavanger University Hospital, Stavanger, Norway
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- Kristjansdottir, Gudlaug (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Molecular Medicine, Department of Medical Sciences, Uppsala University, Uppsala
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- Theander, Elke (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine,Department of Rheumatology, Malmö University Hospital, Malmö
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- Nordmark, Gunnel (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Section of Rheumatology, Department of Medical Sciences, Uppsala University, Uppsala
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- Kvarnström, Marika (author)
- Karolinska Institutet,Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm
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- Eriksson, Per (author)
- Östergötlands Läns Landsting,Linköpings universitet,Reumatologi,Hälsouniversitetet,Njurmedicinska kliniken US
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- Rönnblom, Lars (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Section of Rheumatology, Department of Medical Sciences, Uppsala University, Uppsala
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- Wahren-Herlenius, Marie (author)
- Karolinska Institutet,Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm
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- Jonsson, Roland (author)
- Broegelmann Research Laboratory, The Gade Institute, University of Bergen, Bergen, Norway
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(creator_code:org_t)
- 2011-03-30
- 2011
- English.
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In: Annals of the Rheumatic Diseases. - : BMJ. - 0003-4967 .- 1468-2060. ; 70:7, s. 1327-1329
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Abstract
Subject headings
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- Background: Primary Sjögren's syndrome (pSS) is characterised by a chronic inflammation of exocrine glands. Salivary gland infiltrates, however, do not correlate well with disease symptoms, and a primary role for the salivary gland parenchyma in disease development has been suggested. Specifically, dysfunction of exocrine pathways involving the muscarinic receptor 3 (CHRM3) has been indicated. Objective: To investigate possible genetic divergence in the CHRM3 gene in patients with pSS. Methods: 530 patients with pSS and 532 controls from a combined Swedish and Norwegian cohort were genotyped for 84 single nucleotide polymorphisms (SNPs) distributed throughout CHRM3. Results: Genetic association was observed with five SNPs localised in intron 3 and 4 of CHRM3, the strongest being rs7548522 (minor allele frequency = 0.06, OR=1.93, 95% CI (1.24 to 3.01); p=0.0033). In addition, clinical parameters, including focus score, abnormal Schirmer's test and presence of autoantibodies, were associated with different SNPs in CHRM3. Conclusion: The study demonstrates a novel association of CHRM3 polymorphisms with pSS, suggesting a functional role for CHRM3 and the salivary gland parenchyma in the pathogenesis of pSS.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Appel, Silke
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Le Hellard, Step ...
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Bruland, Ove
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Brun, Johan G.
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Omdal, Roald
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Kristjansdottir, ...
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Theander, Elke
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Nordmark, Gunnel
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Kvarnström, Mari ...
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Eriksson, Per
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Rönnblom, Lars
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Wahren-Herlenius ...
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Jonsson, Roland
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
- Articles in the publication
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Annals of the Rh ...
- By the university
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Uppsala University
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Lund University
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Karolinska Institutet
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Linköping University